New Delhi metallo-beta-lactamase 1 - Wikipedia.
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The Ambler classification system groups known beta-lactamase enzymes into four groups according to sequence homology and presumed phylogenetic relationships. Classes A, C and D cleave beta-lactams by a multi-step mechanism analogous to the mechanism of serine proteases.
Metallo-beta-lactamases result in beta-lactam resistance. The introduction of antibiotics represented one of the most important medical interventions in the history of global health, resulting in a dramatic reduction in human morbidity and mortality caused by bacterial infections (1).
The last group group B or metallo-beta-lactamase (MBL) differs from the three others by the fact that they possess in the active site metallic ions whereas group A, C and D are serine-active enzymes.
INHIBITION OF METALLO-BETA-LACTAMASE BY RNA by KYU MEE KIM, B.S. A THESIS IN. metallo-P-lactamase using RNA generated by SELEX identified a 30-mer RNA, an U-mer RNA, and an undefined random pool of RNA with inhibitory activity. Classification of B-lactamases A wide range of bacteria produces p-lactamases; an incomplete list of bacteria.
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